Arimidex description, Arimidex side effects, Arimidex price, Arimidex substance

Substance: Anastrozole

Anastrozole is a very new drug developed for the treatment of advanced breast cancer in women. It is manufactured by Zenica Pharmaceuticals and was approved for use in the United States at the end of December 1995. Specifically, Anastrozole?® is the first in a new class of third-generation selective oral aromatase inhibitors5?°. It acts by blocking the enzyme aromatase, subsequently blocking the production of estrogen. Since many forms of breast cancer cells are stimulated by estrogen, it is hoped that by reducing amounts of estrogen in the body the progression of such a disease can be halted. This is the basic premise behind Nolvadex?®, except this drug blocks the action and not production of estrogen. The effects of Anastrozole?® can be quite dramatic to say the least. A daily dose of one tablet (1 mg) can produce estrogen suppression greater than 80 % in treated patients. With the powerful effect this drug has on hormone levels, it is only to be used (clinically) by post-menopausal women whose disease has progressed following treatment with Nolvadex?® (tamoxifen citrate). Side effects like hot flushes and hair thinning can be present, and would no doubt be much more severe in pre-menopausal patients.



For the steroid using male athlete, Anastrozole?® shows great potential. Up to this point, drugs like Nolvadex?® and Proviron?® have been our weapons against excess estrogen. These drugs, especially in combination, do prove quite effective. But Anastrozole?® appears able to do the job much more efficiently, and with less hassle. Its use is only now catching on, but early reports have been excellent. A single tablet daily, the same dose use clinically, seems to be all one needs for an exceptional effect (some even report excellent results with only 2 tablet daily). When used with strong, readily aromatizing androgens such as Dianabol or testosterone, gynecomastia and water retention can be effectively blocked. In combination with Propecia?® (finasteride, see Proscar?®), we have a great advance. With the one drug halting estrogen conversion and the other blocking 5-alpha reduction (testosterone, methyltestosterone and Halotestin?® only), related side effects can be effectively minimized. Here the strong androgen testosterone could theoretically provide incredible muscular growth, while at the same time being as tolerable as nandrolone. Additionally the quality of the muscle should be greater, the athlete appearing harder and much more defined without holding excess water.



There are some concerns with using an aromatase inhibitor such as this during prolonged steroid treatment however. While it will effectively reduce estrogenic side effects, it will also block the beneficial properties of estrogen from becoming apparent (namely its effect on cholesterol values). Studies have clearly shown that when an aromatase inhibitor is used in conjunction with a steroid such as testosterone, suppression of HDL (good) cholesterol becomes much more pronounced. Apparently estrogen plays a role in minimizing the negative impact of steroid use. Since the estrogen receptor antagonist Nolvadex?® is shown not to display an antiestrogenic effect on cholesterol values, it is certainly the preferred from of estrogen maintenance for those concerned with cardiovascular health.



Anastrozole?® has another principle drawback, namely the great price of this drug. Tablets can easily sell for $10 each, becoming quite costly with regular use. ! am currently looking at the product list of a reliable European anabolics dealer, who sells Anastrozole?® in packages of 28 tablets for $250. Clearly the price of an ancillary drug can be much greater than the steroids themselves, a situation destined not to be popular with recreational bodybuilders. Competitors on the other hand are likely to welcome this item. It can ward off the side effects of strong androgen therapy much better than Nolvadex?® and/or Proviron?® , making heavy cycles much more comfortable. As the number of countries manufacturing this drug increases, we may be able to look forward to a reduction in price. On a list from a Greek supplier (a country where drugs are government subsidized) for example, the price was nearly $100 better per box. Privately compounded versions of "liquid Arimidex?° have also been formulated "for research purposes" and are currently circulating the black market. They contain a high concentration of anastrozole (1 mg to 4mg/ml) in a liquid solution, which can be used orally, and represent very cost-effective alternatives for buying the brand name drug (typically selling for $5 per milligram or less).

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